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Artículos Médicos

Muchas gracias por visitar el sitio en Internet de AMMIM (Asociación Mexicana de Médicos e Investigadores del Mangostán).

Esta es una sección en la que encontrarás todos los artículos médicos relacionados con el magostán, que hablan de cómo actúa esta maravillosa fruta dentro de nuestro organismo. Sabrás quién lo escribió y de dónde fue sacado o encontrado para que estés 100% seguro de que esta fruta es extraordinaria.

 

 

 

Mangosteen xanthones suppress hepatitis C virus genome replication.

Choi M1, Kim YM, Lee S, Chin YW, Lee C.
Author information: 
1College of Pharmacy, Dongguk University-Seoul, Goyang, 410-050, South Korea.
Abstract
 
Hepatitis C virus (HCV) is a hepatotropic single-stranded RNA virus. HCV infection is causally linked with development of liver cirrhosis and hepatocellular carcinoma. Enhanced production of reactive oxygen species by HCV has been implicated to play an important role in HCV-induced pathogenesis. Mangosteen has been widely used as a traditional medicine as well as a dietary supplement ,thanks to its powerful anti-oxidant effect. In the present study, we demonstrated that the ethanol extract from mangosteen fruit peels (MG-EtOH) is able to block HCV genome replication using HCV genotype 1b Bart79I subgenomic (EC50 5.1 μg/mL) and genotype 2a J6/JFH-1 infectious replicon systems (EC50 3.8 μg/mL). We found that inhibition of HCV replication by MG-EtOH led to subsequent down-regulation of expression of HCV proteins. Interestingly, MG-EtOH exhibited a modest inhibitory effect on in vitro RNA polymerase activity of NS5B. Among a number of xanthones compounds identified within this MG-EtOH, we discovered α-MG (EC50 6.3 μM) and γ-MG (EC50 2.7 μM) as two major single molecules responsible for suppression of HCV replication. This finding will provide a valuable molecular basis to further develop mangosteen as an important dietary supplement to combat HCV-induced liver diseases.
PMID: 24986787 [PubMed - as supplied by publisher]

α-Mangostin suppresses human gastric adenocarcinoma cells in vitro via blockade of Stat3 signaling pathway.

Shan T1, Cui XJ2, Li W3, Lin WR4, Lu HW1, Li YM1, Chen X1, Wu T1.
Author information: 
1Department of General Surgery, Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710004, China.
2Department of General Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
3Graduate School, Fourth Military Medical University, Xi'an 710033, China.
4Department of pathology, Shandong Provincial Hospital, Ji'nan 250021, China.
Abstract
 
Aim:To investigate the anti-tumor effects of α-mangostin, a major xanthone identified in the pericarp of mangosteen (Garcinia mangostana Linn), against human gastric adenocarcinoma cells in vitro, and the mechanisms of the effects.Methods:Human gastric adenocarcinoma cell lines BGC-823 and SGC-7901 were treated with α-mangostin. The cell viability was measured with MTT assay, and cell apoptosis was examined using flow cytometry and TUNEL assay. The expression of the relevant proteins was detected using Western blot.Results:Treatment with α-mangostin (3-10 μg/mL) inhibited the viability of both BGC-823 and SGC-7901 cells in dose- and time-manners. Furthermore, α-mangostin (7 μg/mL) time-dependently increased the apoptosis index of the cancer cells, reduced the mitochondrial membrane potential of the cancer cells, and significantly increased the release of cytochrome c and AIF into cytoplasm. Moreover, the α-mangostin treatment markedly suppressed the constitutive Stat3 protein activation, and Stat3-regulated Bcl-xL and Mcl-1 protein levels in the cancer cells.Conclusion:The anti-tumor effects of α-mangostin against human gastric adenocarcinoma cells in vitro can be partly attributed to blockade of Stat3 signaling pathway.
PMID: 24976157 [PubMed - as supplied by publisher]

Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells.

Li P, Tian W, Ma X1.
Author information: 
1College of Life Sciences, University of Chinese Academy of Sciences, No, 19A Yuquan Road, Beijing 100049, China. Esta dirección electrónica esta protegida contra spambots. Es necesario activar Javascript para visualizarla .
Abstract
 
BACKGROUND:
 
Fatty acid synthase (FAS) has been proven over-expressed in human breast cancer cells and consequently, has been recognized as a target for breast cancer treatment. Alpha-mangostin, a natural xanthone found in mangosteen pericarp, has a variety of biological activities, including anti-cancer effect. In our previous study, alpha-mangostin had been found both fast-binding and slow-binding inhibitions to FAS in vitro. This study was designed to investigate the activity of alpha-mangostin on intracellular FAS activity in FAS over-expressed human breast cancer cells, and to testify whether the anti-cancer activity of alpha-mangostin may be related to its inhibitory effect on FAS.
METHODS:
 
We evaluated the cytotoxicity of alpha-mangostin in human breast cancer MCF-7 and MDA-MB-231 cells. Intracellular FAS activity was measured by a spectrophotometer at 340 nm of NADPH absorption. Cell Counting Kit assay was used to test the cell viability. Immunoblot analysis was performed to detect FAS expression level, intracellular fatty acid accumulation and cell signaling (FAK, ERK1/2 and AKT). Apoptotic effects were detected by flow cytometry and immunoblot analysis of PARP, Bax and Bcl-2. Small interfering RNA was used to down-regulate FAS expression and/or activity.
RESULTS:
 
Alpha-mangostin could effectively suppress FAS expression and inhibit intracellular FAS activity, and result in decrease of intracellular fatty acid accumulation. It could also reduce cell viability, induce apoptosis in human breast cancer cells, increase in the levels of the PARP cleavage product, and attenuate the balance between anti-apoptotic and pro-apoptotic proteins of the Bcl-2 family. Moreover, alpha-mangostin inhibited the phosphorylation of FAK. However, the active forms of AKT, and ERK1/2 proteins were not involved in the changes of FAS expression induced by alpha-mangostin.
CONCLUSIONS:
 
Alpha-mangostin induced breast cancer cell apoptosis by inhibiting FAS, which provide a basis for the development of xanthone as an agent for breast cancer therapy.
PMCID: PMC4060095 
PMID: 24894151 [PubMed - in process]

α-Mangostin suppresses the viability and epithelial-mesenchymal transition of pancreatic cancer cells by downregulating the PI3K/Akt pathway.

Xu Q1, Ma J2, Lei J1, Duan W1, Sheng L1, Chen X1, Hu A1, Wang Z1, Wu Z1, Wu E3, Ma Q1, Li X4.
 
Author information: 
1Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
2Department of Oncology, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
3Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58105, USA.
4Department of General Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Abstract
 
α -Mangostin, a natural product isolated from the pericarp of the mangosteen fruit, has been shown to inhibit the growth of tumor cells in various types of cancers. However, the underlying molecular mechanisms are largely unclear. Here, we report that α -mangostin suppressed the viability and epithelial-mesenchymal transition (EMT) of pancreatic cancer cells through inhibition of the PI3K/Akt pathway. Treatment of pancreatic cancer BxPc-3 and Panc-1 cells with α -mangostin resulted in loss of cell viability, accompanied by enhanced cell apoptosis, cell cycle arrest at G1 phase, and decrease of cyclin-D1. Moreover, Transwell and Matrigel invasion assays showed that α -mangostin significantly reduced the migration and invasion of pancreatic cancer cells. Consistent with these results, α -mangostin decreased the expression of MMP-2, MMP-9, N-cadherin, and vimentin and increased the expression of E-cadherin. Furthermore, we found that α -mangostin suppressed the activity of the PI3K/Akt pathway in pancreatic cancer cells as demonstrated by the reduction of the Akt phosphorylation by α -mangostin. Finally, α -mangostin significantly inhibited the growth of BxPc-3 tumor mouse xenografts. Our results suggest that α -mangostin may be potentially used as a novel adjuvant therapy or complementary alternative medicine for the management of pancreatic cancers.
PMCID: PMC4000937 
PMID: 24812621 [PubMed - in process]
 

A new xanthone from the pericarp of Garcinia mangostana.

Fu M1Qiu SX2Xu Y3Wu J3Chen Y3Yu Y3Xiao G3.
 
1Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China Esta dirección electrónica esta protegida contra spambots. Es necesario activar Javascript para visualizarla
2Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P.R. China.
3Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China
 
Abstract
 
A new prenylxanthone, garcimangostanol (1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-isomangostin (3), and garcinone C (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR and MS data. Compounds 1-4 exhibited either significant o r moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro with IC50 values from 4.0 +/- 0.3 to 23.6+/- 1.5 microM by MTT colorimetric assay.
 
PMID:
 
24555285
 
[PubMed - indexed for MEDLINE]

Los efectos antialérgicos y antinflamatorios del extracto de butanol Arctium lappa*

 

altAnti-allergic and anti-inflammatory effects of butanol extract from
Arctium Lappa
 
L.Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, Kim
SY.
 
Department of Pediatrics, College of Medicine, Hanyang University,
Seoul, 133-792, Korea.
 
Abstract
 
BACKGROUND:
Atopic dermatitis is a chronic, allergic inflammatory skin disease that is accompanied by markedly increased levels of inflammatory cells, including eosinophils, mast cells, and T cells. Arctium lappa
 
L. is a traditional medicine in Asia. This study examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.
METHODS:
 
This study examined the effect of ALBE on the release of β-hexosaminidase in antigen-stimulated-RBL-2H3 cells. We also evaluated the ConA-induced expression of IL-4, IL-5, mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)-κB using RT-PCR, Western blotting, and ELISA in mouse splenocytes after ALBE treatment.
 
RESULTS:
 
We observed significant inhibition of β-hexosaminidase release in RBL-2H3 cells and suppressed mRNA expression and protein secretion of IL-4 and IL-5 induced by ConA-treated primary murine splenocytes after ALBE treatment. Additionally, ALBE (100 μg/mL) suppressed not only the transcriptional activation of NF-κB, but also the phosphorylation of MAPKs in ConA-treated primary splenocytes.
 
CONCLUSIONS:
 
These results suggest that ALBE inhibits the expression of IL-4 and IL-5 by downregulating MAPKs and NF-κB activation in ConA-treated splenocytes and supports the hypothesis that ALBE may have beneficial effects in the treatment of allergic diseases, including atopic dermatitis.PMCID: PMC3045362 Free PMC Article
 
High-sensitivity C-reactive Protein is a Predictive Factor of Adiposity in Children: Results of the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) Study.Nappo A, Iacoviello L, Fraterman A, Gonzalez-Gil EM, Hadjigeorgiou C, Marild S, Molnar D, Moreno LA, Peplies J, Sioen I, Veidebaum T, Siani A, Russo P. Unit of Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy.
 
Abstract
 
BACKGROUND:
 
Whereas cross-sectional studies have shown that obesity is associated with increased C-reactive protein (CRP) levels in children, little is
known about the impact of low-grade inflammation on body mass changes during growth.
 
METHODS AND RESULTS:
 
We assessed cross-sectionally and longitudinally the association ofhigh-sensitivity (hs)-CRP levels with overweight/obesity and related cardiometabolic risk factors in the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) cohort. 16 224 children from 8 European countries (2 to 9 years) were recruited during the baseline survey (T0). After the exclusion of 7187 children because of missing hs-CRP measurements and 2421 because of drug use during the previous week, the analysis was performed on 6616 children (Boys=3347; Girls=3269; age=6.3±1.7 years). Of them, 4110 were reexamined 2 years later (T1). Anthropometric variables, blood pressure, hs-CRP, blood lipids, glucose and insulin were measured. The population at T0 was divided into 3 categories, according to the baseline hs-CRP levels. Higher hs-CRP levels were associated with significantly higher prevalence of overweight/obesity, body mass index (BMI) z-score and central adiposity indices (P values all <0.0001), and with higher blood pressure and lower HDL-cholesterol
levels. Over the 2-year follow-up, higher baseline hs-CRP levels were associated with a significant increase in BMI z-score (P<0.001) and significantly higher risk of incident overweight/obesity.
 
CONCLUSIONS:
 
Higher hs-CRP levels are associated to higher body mass and
overweight/obesity risk in a large population of European children.
 
Children with higher baseline levels of hs-CRP had a greater increase
in BMI z-score and central adiposity over time and were at higher risk
of developing overweight/obesity during growth.
 
A review of the pharmacological effects of Arctium lappa
(burdock).Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW.
State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, SAR, People's Republic of China.
 
Abstract
 
Arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy and nutritive food in Chinese societies. Burdock has been used therapeutically in Europe, North America and Asia for hundreds of years. The roots, seeds and leaves of burdock have been investigated in view of its popular uses in traditional Chinese medicine (TCM). In this review, the reported therapeutic effects of the active compounds present in the different botanical parts of burdock are summarized. In the root, the active ingredients have been found to "detoxify" blood in terms of TCM and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema. Antioxidants and antidiabetic compounds have also been found in the root. In the seeds, some active compounds possess anti-inflammatory effects and potent inhibitory effects on the growth of tumors such as pancreatic carcinoma. In the leaf extract, the active compounds isolated can inhibit the growth of micro-organisms in the oral cavity. The medicinal uses of burdock in treating chronic diseases such as cancers, diabetes and AIDS have been reported.
 
However, it is also essential to be aware of the side effects of burdock including contact dermatitis and other allergic/inflammatory responses that might be evoked by burdock.
 
Nota: * constituyente del smoth tea

Tuberculosis y mangostán. Publicación de PubMed

alt1.Chem Pharm Bull (Tokyo). 2012 Nov 12. 

 
Potent Activity against Multidrug-resistant Mycobacterium tuberculosis of α-Mangostin Analogs.
 
Sudta P, Jiarawapi P, Suksamrarn A, Hongmanee P, Suksamrarn S.
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University.
 
Abstract
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H(37)Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with MIC of 0.78μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the MDR strains with pronounced MICs of 0.78-1.56 μg/mL.
 
 
 
PMID: 23150066
 

Opinión médica sobre el mangostán

Lamentablemente poca gente invierte en su salud, lo común es gastar en la enfermedad.
Dra. Angelita Martin Ferreira. Alergóloga e inmunóloga pediatra. Certificada 2012

altSiempre he pensado que la prevención es la clave para preservar nuestra salud, es tomar las medidas hoy para evitar un mal mañana, impulsemos entonces la prevención para no tener que pagar al final una factura muy alta.

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Mangostán y asma.

altMangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma.
Jang HY, Kwon OK, Oh SR, Lee HK, Ahn KS, Chin YW.


Source
Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea.

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