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Artículos Médicos

Muchas gracias por visitar el sitio en Internet de AMMIM (Asociación Mexicana de Médicos e Investigadores del Mangostán).

Esta es una sección en la que encontrarás todos los artículos médicos relacionados con el magostán, que hablan de cómo actúa esta maravillosa fruta dentro de nuestro organismo. Sabrás quién lo escribió y de dónde fue sacado o encontrado para que estés 100% seguro de que esta fruta es extraordinaria.

Tuberculosis y mangostán. Publicación de PubMed

Sección: Premier -

Artículos Médicos

alt 1.Chem Pharm Bull (Tokyo). 2012 Nov 12.

Potent Activity against Multidrug-resistant Mycobacterium tuberculosis of α-Mangostin Analogs.

Sudta P, Jiarawapi P, Suksamrarn A, Hongmanee P, Suksamrarn S.

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University.

Abstract

A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H(37)Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with MIC of 0.78μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the MDR strains with pronounced MICs of 0.78-1.56 μg/mL.

PMID: 23150066

Opinión médica sobre el mangostán

Sección: Premier -

Artículos Médicos

Lamentablemente poca gente invierte en su salud, lo común es gastar en la enfermedad.
Dra. Angelita Martin Ferreira. Alergóloga e inmunóloga pediatra. Certificada 2012

alt Siempre he pensado que la prevención es la clave para preservar nuestra salud, es tomar las medidas hoy para evitar un mal mañana, impulsemos entonces la prevención para no tener que pagar al final una factura muy alta.

Mangostán y asma.

Sección: Premier -

Artículos Médicos

alt Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma.
Jang HY, Kwon OK, Oh SR, Lee HK, Ahn KS, Chin YW.

Source
Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea.

Cáncer de colon y mangostán

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Artículos Médicos

Gamma-Mangostin, a Micronutrient of Mangosteen Fruit, Induces Apoptosis in Human Colon Cancer Cells.
Chang HF, Yang LL.

Source
Department of Pharmacognosy, School of Pharmacy, College of Pharmacy, and Center of e-CAM, Taipei Medical University, 250 Wusing St., Taipei 110, Taiwan. Esta dirección electrónica esta protegida contra spambots. Es necesario activar Javascript para visualizarla .

Mangostán y cáncer

Sección: Premier -

Artículos Médicos

alt Food Chem Toxicol. 2012 Jun 12.
Anti-skin cancer properties of phenolic-rich extract from the pericarp of mangosteen (Garcinia mangostana Linn.).
Wang JJ, Shi QH, Zhang W, Sanderson BJ.

Source
Level 4, Health Science Building, Department of Medical Biotechnology, Flinders Medical Sciences and Technology, School of Medicine, Faculty of Health Science, Flinders University, Registry Road, Bedford Park, Adelaide, Australia, 5042; Level 4, Health Science Building, Flinders Centre for Marine Bioproducts Development (FCMBD), Flinders University, Registry Road, Bedford Park, Adelaide, Australia, 5042.

Abstract
Skin cancers are often resistant to conventional chemotherapy. This study examined the anti-skin cancer properties of crude ethanol extract of mangosteen pericarp (MPEE) on human squamous cell carcinoma A-431 and melanoma SK-MEL-28 lines. Significant dose-dependent reduction in% viability was observed for these cell lines, with less effect on human normal skin fibroblast CCD-1064Sk and keratinocyte HaCaT cell lines. Cell distribution in G(1) phase (93%) significantly increased after 10 μg/ml of MPEE versus untreated SK-MEL-28 cells (78%), which was associated with enhanced p21(WAF1) mRNA levels. In A-431 cells, 10 μg/ml MPEE significantly increased the sub G(1) peak (15%) with concomitant decrease in G(1) phase over untreated cells (2%). In A-431 cells, 10 μg/ml MPEE induced an 18% increase in early apoptosis versus untreated cells (2%). This was via caspase activation (15-, 3- and 4-fold increased caspse-3/7, 8, and 9 activities), and disruption of mitochondrial pathways (6-fold decreased mitochondrial membrane potential versus untreated cells). Real-time PCR revealed increased Bax/Bcl-2 ratio and cytochrome c release, and decreased Akt1. Apoptosis was significantly increased after MPEE treatment of SK-MEL-28 cells. Hence, MPEE showed strong anti-skin cancer effect on these two skin cancer cell lines, with potential as an anti-skin cancer agent.
Copyright © 2012. Published by Elsevier Ltd.

PMID: 22705325 [PubMed - as supplied by publisher]

Estudios descubren menor riesgo de cáncer con la dosis diaria de Aspirina

Sección: Premier -

Artículos Médicos

S

tudies Link Daily Doses of Aspirin to Reduced Risk of Cancer

By RONI CARYN RABIN

Published: March 20, 2012

Taking aspirin every day may significantly reduce the risk of many cancers and prevent tumors from spreading, according to two new studies published on Tuesday.

The findings add to a body of evidence suggesting that cheap and widely available aspirin may be a powerful if overlooked weapon in the battle against cancer. But the research also poses difficult questions for doctors and public health officials, as regular doses of aspirin can cause gastrointestinal bleeding and other side effects. Past studies have suggested that the drawbacks of daily use may outweigh the benefits, particularly in healthy patients.

Caracterización estructural, los efectos biológicos y sintéticos del mangostán

Sección: Premier -

Artículos Médicos

alt

NIH Public Access

Author Manuscript

Mini Rev Org Chem. Author manuscript; available in PMC 2011 May 9.

Published in final edited form as:

Mini Rev Org Chem. 2008 November 1; 5(4): 355–364. doi:10.2174/157019308786242223

Structural Characterization, Biological Effects, and Synthetic

Studies on Xanthones from Mangosteen (Garcinia mangostana),

a Popular Botanical Dietary Supplement

Young-Won Chin* and A. Douglas Kinghorn

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State

University, Columbus, OH 43210, USA

Abstract

Mangosteen (Garcinia mangostana L., Clusiaceae) is a popular botanical dietary supplement in

the United States, where it is used principally as an antioxidant. It is referred to as the “queen of

fruits” in Thailand, a country of origin. The major secondary metabolites of mangosteen, the

xanthones, exhibit a variety of biological activities including antibacterial, antifungal,

antiinflammatory, antioxidant, antiplasmodial, cytotoxic, and potential cancer chemopreventive

activities. Moreover, some of the xanthones from mangosteen have been found to influence

specific enzyme activities, such as aromatase, HIV-1 protease, inhibitor κB kinase, quinone

reductase, sphingomyelinase, topoisomerase and several protein kinases, and they also modulate

histamine H1 and 5-hydroxytryptamine2A receptor binding. Several synthetic procedures for active

xanthones and their analogs have been conducted to obtain a better insight into structure-activity

relationships for this compound class. This short review deals with progress made in the structural

characterization of the chemical constituents of mangosteen, as well as the biological activity of

pure constituents of this species and synthetic methods for the mangosteen xanthones.

Portal AMMIM

Artículos Médicos

Tuberculosis y mangostán. Publicación de PubMed

Opinión médica sobre el mangostán

Mangostán y asma.

Cáncer de colon y mangostán

Mangostán y cáncer

Estudios descubren menor riesgo de cáncer con la dosis diaria de Aspirina

Caracterización estructural, los efectos biológicos y sintéticos del mangostán

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