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Artículos Médicos

Muchas gracias por visitar el sitio en Internet de AMMIM (Asociación Mexicana de Médicos e Investigadores del Mangostán).

Esta es una sección en la que encontrarás todos los artículos médicos relacionados con el magostán, que hablan de cómo actúa esta maravillosa fruta dentro de nuestro organismo. Sabrás quién lo escribió y de dónde fue sacado o encontrado para que estés 100% seguro de que esta fruta es extraordinaria.




Los efectos antialérgicos y antinflamatorios del extracto de butanol Arctium lappa*


altAnti-allergic and anti-inflammatory effects of butanol extract from
Arctium Lappa
L.Sohn EH, Jang SA, Joo H, Park S, Kang SC, Lee CH, Kim
Department of Pediatrics, College of Medicine, Hanyang University,
Seoul, 133-792, Korea.
Atopic dermatitis is a chronic, allergic inflammatory skin disease that is accompanied by markedly increased levels of inflammatory cells, including eosinophils, mast cells, and T cells. Arctium lappa
L. is a traditional medicine in Asia. This study examined whether a butanol extract of A. lappa (ALBE) had previously unreported anti-allergic or anti-inflammatory effects.
This study examined the effect of ALBE on the release of β-hexosaminidase in antigen-stimulated-RBL-2H3 cells. We also evaluated the ConA-induced expression of IL-4, IL-5, mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)-κB using RT-PCR, Western blotting, and ELISA in mouse splenocytes after ALBE treatment.
We observed significant inhibition of β-hexosaminidase release in RBL-2H3 cells and suppressed mRNA expression and protein secretion of IL-4 and IL-5 induced by ConA-treated primary murine splenocytes after ALBE treatment. Additionally, ALBE (100 μg/mL) suppressed not only the transcriptional activation of NF-κB, but also the phosphorylation of MAPKs in ConA-treated primary splenocytes.
These results suggest that ALBE inhibits the expression of IL-4 and IL-5 by downregulating MAPKs and NF-κB activation in ConA-treated splenocytes and supports the hypothesis that ALBE may have beneficial effects in the treatment of allergic diseases, including atopic dermatitis.PMCID: PMC3045362 Free PMC Article
High-sensitivity C-reactive Protein is a Predictive Factor of Adiposity in Children: Results of the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) Study.Nappo A, Iacoviello L, Fraterman A, Gonzalez-Gil EM, Hadjigeorgiou C, Marild S, Molnar D, Moreno LA, Peplies J, Sioen I, Veidebaum T, Siani A, Russo P. Unit of Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy.
Whereas cross-sectional studies have shown that obesity is associated with increased C-reactive protein (CRP) levels in children, little is
known about the impact of low-grade inflammation on body mass changes during growth.
We assessed cross-sectionally and longitudinally the association ofhigh-sensitivity (hs)-CRP levels with overweight/obesity and related cardiometabolic risk factors in the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) cohort. 16 224 children from 8 European countries (2 to 9 years) were recruited during the baseline survey (T0). After the exclusion of 7187 children because of missing hs-CRP measurements and 2421 because of drug use during the previous week, the analysis was performed on 6616 children (Boys=3347; Girls=3269; age=6.3±1.7 years). Of them, 4110 were reexamined 2 years later (T1). Anthropometric variables, blood pressure, hs-CRP, blood lipids, glucose and insulin were measured. The population at T0 was divided into 3 categories, according to the baseline hs-CRP levels. Higher hs-CRP levels were associated with significantly higher prevalence of overweight/obesity, body mass index (BMI) z-score and central adiposity indices (P values all <0.0001), and with higher blood pressure and lower HDL-cholesterol
levels. Over the 2-year follow-up, higher baseline hs-CRP levels were associated with a significant increase in BMI z-score (P<0.001) and significantly higher risk of incident overweight/obesity.
Higher hs-CRP levels are associated to higher body mass and
overweight/obesity risk in a large population of European children.
Children with higher baseline levels of hs-CRP had a greater increase
in BMI z-score and central adiposity over time and were at higher risk
of developing overweight/obesity during growth.
A review of the pharmacological effects of Arctium lappa
(burdock).Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW.
State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, SAR, People's Republic of China.
Arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy and nutritive food in Chinese societies. Burdock has been used therapeutically in Europe, North America and Asia for hundreds of years. The roots, seeds and leaves of burdock have been investigated in view of its popular uses in traditional Chinese medicine (TCM). In this review, the reported therapeutic effects of the active compounds present in the different botanical parts of burdock are summarized. In the root, the active ingredients have been found to "detoxify" blood in terms of TCM and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema. Antioxidants and antidiabetic compounds have also been found in the root. In the seeds, some active compounds possess anti-inflammatory effects and potent inhibitory effects on the growth of tumors such as pancreatic carcinoma. In the leaf extract, the active compounds isolated can inhibit the growth of micro-organisms in the oral cavity. The medicinal uses of burdock in treating chronic diseases such as cancers, diabetes and AIDS have been reported.
However, it is also essential to be aware of the side effects of burdock including contact dermatitis and other allergic/inflammatory responses that might be evoked by burdock.
Nota: * constituyente del smoth tea

Tuberculosis y mangostán. Publicación de PubMed

alt1.Chem Pharm Bull (Tokyo). 2012 Nov 12. 

Potent Activity against Multidrug-resistant Mycobacterium tuberculosis of α-Mangostin Analogs.
Sudta P, Jiarawapi P, Suksamrarn A, Hongmanee P, Suksamrarn S.
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University.
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H(37)Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with MIC of 0.78μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the MDR strains with pronounced MICs of 0.78-1.56 μg/mL.
PMID: 23150066

Opinión médica sobre el mangostán

Lamentablemente poca gente invierte en su salud, lo común es gastar en la enfermedad.
Dra. Angelita Martin Ferreira. Alergóloga e inmunóloga pediatra. Certificada 2012

altSiempre he pensado que la prevención es la clave para preservar nuestra salud, es tomar las medidas hoy para evitar un mal mañana, impulsemos entonces la prevención para no tener que pagar al final una factura muy alta.

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Mangostán y asma.

altMangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma.
Jang HY, Kwon OK, Oh SR, Lee HK, Ahn KS, Chin YW.

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea.

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Cáncer de colon y mangostán

altGamma-Mangostin, a Micronutrient of Mangosteen Fruit, Induces Apoptosis in Human Colon Cancer Cells.
Chang HF, Yang LL.

Department of Pharmacognosy, School of Pharmacy, College of Pharmacy, and Center of e-CAM, Taipei Medical University, 250 Wusing St., Taipei 110, Taiwan. Esta dirección electrónica esta protegida contra spambots. Es necesario activar Javascript para visualizarla .

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Mangostán y cáncer

altFood Chem Toxicol. 2012 Jun 12.
Anti-skin cancer properties of phenolic-rich extract from the pericarp of mangosteen (Garcinia mangostana Linn.).
Wang JJ, Shi QH, Zhang W, Sanderson BJ.

Level 4, Health Science Building, Department of Medical Biotechnology, Flinders Medical Sciences and Technology, School of Medicine, Faculty of Health Science, Flinders University, Registry Road, Bedford Park, Adelaide, Australia, 5042; Level 4, Health Science Building, Flinders Centre for Marine Bioproducts Development (FCMBD), Flinders University, Registry Road, Bedford Park, Adelaide, Australia, 5042.

Skin cancers are often resistant to conventional chemotherapy. This study examined the anti-skin cancer properties of crude ethanol extract of mangosteen pericarp (MPEE) on human squamous cell carcinoma A-431 and melanoma SK-MEL-28 lines. Significant dose-dependent reduction in% viability was observed for these cell lines, with less effect on human normal skin fibroblast CCD-1064Sk and keratinocyte HaCaT cell lines. Cell distribution in G(1) phase (93%) significantly increased after 10 μg/ml of MPEE versus untreated SK-MEL-28 cells (78%), which was associated with enhanced p21(WAF1) mRNA levels. In A-431 cells, 10 μg/ml MPEE significantly increased the sub G(1) peak (15%) with concomitant decrease in G(1) phase over untreated cells (2%). In A-431 cells, 10 μg/ml MPEE induced an 18% increase in early apoptosis versus untreated cells (2%). This was via caspase activation (15-, 3- and 4-fold increased caspse-3/7, 8, and 9 activities), and disruption of mitochondrial pathways (6-fold decreased mitochondrial membrane potential versus untreated cells). Real-time PCR revealed increased Bax/Bcl-2 ratio and cytochrome c release, and decreased Akt1. Apoptosis was significantly increased after MPEE treatment of SK-MEL-28 cells. Hence, MPEE showed strong anti-skin cancer effect on these two skin cancer cell lines, with potential as an anti-skin cancer agent.
Copyright © 2012. Published by Elsevier Ltd.

PMID: 22705325 [PubMed - as supplied by publisher]

Estudios descubren menor riesgo de cáncer con la dosis diaria de Aspirina


Salttudies Link Daily Doses of Aspirin to Reduced Risk of Cancer
Published: March 20, 2012
Taking aspirin every day may significantly reduce the risk of many cancers and prevent tumors from spreading, according to two new studies published on Tuesday.
The findings add to a body of evidence suggesting that cheap and widely available aspirin may be a powerful if overlooked weapon in the battle against cancer. But the research also poses difficult questions for doctors and public health officials, as regular doses of aspirin can cause gastrointestinal bleeding and other side effects. Past studies have suggested that the drawbacks of daily use may outweigh the benefits, particularly in healthy patients.

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Caracterización estructural, los efectos biológicos y sintéticos del mangostán



NIH Public Access
Author Manuscript
Mini Rev Org Chem. Author manuscript; available in PMC 2011 May 9.
Published in final edited form as:
Mini Rev Org Chem. 2008 November 1; 5(4): 355–364. doi:10.2174/157019308786242223
Structural Characterization, Biological Effects, and Synthetic
Studies on Xanthones from Mangosteen (Garcinia mangostana),
a Popular Botanical Dietary Supplement
Young-Won Chin* and A. Douglas Kinghorn
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State
University, Columbus, OH 43210, USA
Mangosteen (Garcinia mangostana L., Clusiaceae) is a popular botanical dietary supplement in
the United States, where it is used principally as an antioxidant. It is referred to as the “queen of
fruits” in Thailand, a country of origin. The major secondary metabolites of mangosteen, the
xanthones, exhibit a variety of biological activities including antibacterial, antifungal,
antiinflammatory, antioxidant, antiplasmodial, cytotoxic, and potential cancer chemopreventive
activities. Moreover, some of the xanthones from mangosteen have been found to influence
specific enzyme activities, such as aromatase, HIV-1 protease, inhibitor κB kinase, quinone
reductase, sphingomyelinase, topoisomerase and several protein kinases, and they also modulate
histamine H1 and 5-hydroxytryptamine2A receptor binding. Several synthetic procedures for active
xanthones and their analogs have been conducted to obtain a better insight into structure-activity
relationships for this compound class. This short review deals with progress made in the structural
characterization of the chemical constituents of mangosteen, as well as the biological activity of
pure constituents of this species and synthetic methods for the mangosteen xanthones.

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