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Artículo de PubMed

altNational Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).

PubMed 
J Agric Food Chem. 2013 Apr 11. 
 
α-Mangostin: Anti-Inflammatory Activity and Metabolism by Human Cells.
Gutierrez-Orozco F, Chitchumroonchokchai C, Lesinski GB,
Suksamrarn S, Failla ML.
Interdisciplinary Ph.D. Program in Nutrition, Human Nutrition
Program, Department of Internal Medicine, The Ohio State University ,
Columbus, Ohio 43210, United States.
 
Abstract
Information about the anti-inflammatory activity and metabolism of
α-mangostin (α-MG), the most abundant xanthone in mangosteen fruit, in
human cells is limited. On the basis of available literature, we
hypothesized that α-MG will inhibit the secretion of pro-inflammatory
mediators by control and activated macrophage-like THP-1, hepatic
HepG2, enterocyte-like Caco-2, and colon HT-29 human cell lines, as
well as primary human monocyte-derived macrophages (MDM), and that
such activity would be influenced by the extent of metabolism of the
xanthone. α-MG attenuated TNF-α and IL-8 secretion by the various cell
lines but increased TNF-α output by both quiescent and LPS-treated
MDM. The relative amounts of free and phase II metabolites of α-MG and
other xanthones present in media 24 h after addition of α-MG was shown
to vary by cell type and inflammatory insult. Increased transport of
xanthones and their metabolites across Caco-2 cell monolayers
suggests enhanced absorption during an inflammatory episode. The
anti-inflammatory activities of xanthones and their metabolites in
different tissues merit consideration.

Anti-angiogenic effect of α-mangostin.

 

J Nat Med. 2012 Mar 2. [Epub ahead of print]
 
Anti-angiogenic effect of α-mangostin.
 
Shiozaki T, Fukai M, Hermawati E, Juliawaty LD, Syah YM, Hakim EH, Puthongking P, Suzuki T, Kinoshita K, Takahashi K, Koyama K.
 
Source
 
Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan.
 
Abstract
 
Eleven known prenyl xanthones, isolated from the pericarp of Garcinia mangostana, were tested for their ability to inhibit the phosphorylation of kinase domain receptor (KDR) tyrosine kinase. α-Mangostin was found to inhibit phosphorylation of KDR. α-Mangostin also showed to inhibit phosphorylation of the Y1175 residue of KDR (10 μM). This is the first report that α-mangostin inhibited the phosphorylation of KDR tyrosine kinase and also the Y1175 residue of KDR. α-Mangostin also showed inhibitory effects on proliferation of human umbilical vein endothelial cells (HUVECs) (IC(50) 1.2 μM) and human umbilical artery endothelial cells (IC(50) 2.4 μM), as well as the migration (IC(50) 0.034 μM) and tubule formation (at the concentrations of 0.6 and 1.2 μM) of HUVECs. These results suggest that the inhibition of the phosphorylation of KDR tyrosine kinase is concerned in the anti-angiogenic activity of α-mangostin.
 
 
PMID: 22382862

Anti-angiogenic effect of α-mangostin.

 


J Nat Med. 2012 Mar 2. [Epub ahead of print]
 
Anti-angiogenic effect of α-mangostin.
 
Shiozaki T, Fukai M, Hermawati E, Juliawaty LD, Syah YM, Hakim EH, Puthongking P, Suzuki T, Kinoshita K, Takahashi K, Koyama K.
 
Source
 
Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan.
 
Abstract
 
Eleven known prenyl xanthones, isolated from the pericarp of Garcinia mangostana, were tested for their ability to inhibit the phosphorylation of kinase domain receptor (KDR) tyrosine kinase. α-Mangostin was found to inhibit phosphorylation of KDR. α-Mangostin also showed to inhibit phosphorylation of the Y1175 residue of KDR (10 μM). This is the first report that α-mangostin inhibited the phosphorylation of KDR tyrosine kinase and also the Y1175 residue of KDR. α-Mangostin also showed inhibitory effects on proliferation of human umbilical vein endothelial cells (HUVECs) (IC(50) 1.2 μM) and human umbilical artery endothelial cells (IC(50) 2.4 μM), as well as the migration (IC(50) 0.034 μM) and tubule formation (at the concentrations of 0.6 and 1.2 μM) of HUVECs. These results suggest that the inhibition of the phosphorylation of KDR tyrosine kinase is concerned in the anti-angiogenic activity of α-mangostin.
 
 
PMID: 22382862

Efecto antiproliferativo de α-mangostin en células de osteosarcoma canino.

alt

Res Vet Sci. 2012 Feb 16.
 
 
Antiproliferative effect of α-mangostin on canine osteosarcoma cells.
 
Krajarng A, Nilwarankoon S, Suksamrarn S, Watanapokasin R.
 
 
 
Source
Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
 
Abstract
Osteosarcoma is the most frequently diagnosed primary bone tumor in dog. Since chemotherapeutics are quite limited due to high cost and severe toxicity, therefore, the ultimate goal is to discover cost-effective therapeutics with less toxicity. We have studied the effect of α-mangostin, a xanthone derivative isolated from pericarp of mangosteen (Garcinia mangostana Linn.) in canine osteosarcoma, D-17 cells. The results showed that α-mangostin induced antiproliferation with IC(50) at 15μg/ml. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that α-mangostin could induce nuclear condensation and fragmentation, typically seen in apoptosis. Cell cycle analysis demonstrated that α-mangostin induced sub-G1 peak. In addition, α-mangostin also induced membrane flipping of the phosphatidylserine and the loss of mitochondrial membrane potential in D-17 cells. In conclusion, α-mangostin, induced apoptotic cell death against canine osteosarcoma D-17 cells, could be a potential candidate for preventive and therapeutic application for bone cancer treatment in dogs.
 
 
 
Copyright © 2012 Elsevier Ltd. All rights reserved.

 

Últimas publicaciones en PubMed acerca del mangostán

altJ Med Food. 2011 Sep 23

Protective Effect of α-Mangostin on Cardiac Reperfusion Damage by Attenuation of Oxidative Stress.

Buelna-Chontal M, Correa F, Hernández-Reséndiz S, Zazueta C, Pedraza-Chaverri J.

Source

1 Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico , Mexico City, Mexico .

Abstract

Abstract This study was designed to investigate if α-mangostin (α-M), a xanthone present in the pericarp of Garcinia mangostana L., was able to protect against reperfusion injury in Langendorff-reperfused hearts. It was observed that α-M maintains the cardiac mechanical work, diminishes the area of infarct, and prevents the decrease in cardiac ATP and phosphocreatine levels in the reperfused myocardium. The protective effect of this xanthone was associated with reduction of oxidative stress. α-M treatment prevented reperfusion injury-induced protein oxidation (protein carbonyl content), lipid peroxidation (malondialdehyde and 4-hydroxynonenal content), and diminution of glutathione content. In fact, after α-M treatment, the values in these parameters were comparable to those obtained in nonreperfused hearts. In summary, α-M induces a protective effect in postischemic heart associated to the prevention of oxidative stress secondary to reperfusion injury.

_______________________________________________________________________________________

 

Nat Prod Commun. 2011 Sep;6(9):1267-8.

Antifibrotic constituents from Garcinia mangostana.

Chin YW, Shin E, Hwang BY, Lee MK.

Source

College of Pharmacy, Dongguk University-Seoul, Seoul 100-715, Korea.

Abstract

From the CHCl3-soluble fraction of the fruits of Garcinia mangostana (Clusiaceae), six xanthone derivatives, alpha-mangostin (1), gamma-mangostin (2), gartanin (3), deoxygartanin (4), 1-isomangstanin (5) and garcinone E (6), were isolated. All these compounds significantly inhibited HSC-T6 viability as assessed by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Among them, compounds 1 and 2, the most potent and major constituents of G. mangostana, inhibited HSC-T6 viability in dose- and time-dependent manners. In addition, compounds 1 and 2 significantly reduced collagen content, a pathological characteristic of liver fibrosis. Taken together, G. mangostana and its constituents might be beneficial for the treatment of liver fibrosis.

 

_____________________________________________________________________

 

Neuropharmacology. 2011 Sep 24

α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation.

Wang Y, Xia Z, Xu JR, Wang YX, Hou LN, Qiu Y, Chen HZ.

Source

Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of β-sheet-rich amyloid oligomers or fibrils which are associated with cellular toxicity in the brain. Inhibition of Aβ aggregation could be a viable therapeutic strategy for slowing and/or preventing the progress of AD. Here we reported that α-mangostin (α-M), a polyphenolic xanthone derivative from mangosteen, concentration-dependently attenuated the neurotoxicity induced by Aβ-(1-40) or Aβ-(1-42) oligomers (EC(50) = 3.89 nM, 4.14 nM respectively) as observed by decreased cell viability and impaired neurite outgrowth in primary rat cerebral cortical neurons. Molecular docking and dynamics simulations demonstrated that α-M could potentially bind to Aβ and stabilize α-helical conformation. α-M was found to directly dissociate Aβ-(1-40) and Aβ-(1-42) oligomers by blotting with oligomer-specific antibodies. ThioflavinT fluorescence assay and electron microscopy imaging further demonstrated that α-M blocked the fibril formation as well as disturbed the pre-formed fibrils. Taken together, our results indicate that α-M is capable to inhibit and dissociate the Aβ aggregation, which could contribute to its effect of attenuating Aβ oligomers-induced neurotoxicity. Thus, α-M could be a great potential candidate for AD treatment.

Copyright © 2011 Elsevier Ltd. All rights reserved.

 

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Oncology (Williston Park). 2011 Aug;25(9):844.

Mangosteen (Garcinia mangostana).

Cassileth B.

Source

Memorial Sloan-Kettering Cancer Center, New York, New York, USA

 

Buenos Consejos Médicos...

Queridos Amigos, como médico les mando información que espero la apliquen en sus hábitos alimentarios, y que por favor difundan esta información a sus familiares y amigos, debemos cuidar nuestra salud física y mental porque así nuestra calidad de vida es excelente.

Un abrazo

Dra. Syayna S. A


 

 

CUIDA TU SALUD Y LA DE LOS TUYOS

UN FUERTE ABRAZO

LUEGO DE LA OPINIÓN DE LOS "MÉDICOS EXPERTOS", HAGAMOS ...CASO.

 

Favor leer y poner en práctica. Es vital para tu salud física, mental y emocional.


Los alimentos "Top-five" causantes de cáncer:1. Salchichas y embutidos
Porque son altos en nitratos de sodio. La "Cancer Prevention Coalition" advierte que los niños no deben comer más de 12 salchichas al mes. Si no puedes vivir sin las salchichas, compra de las que son hechas SIN nitrato de sodio.
2. Carnes procesadas y tocino (tocino, prosciutto, etc.).
También contiene altos niveles de nitrato de sodio, que además, incrementan el riesgo de enfermedades del corazón. La grasa saturada en el tocino también es un gran colaborador en la generación de cáncer.
3. Donas
Las Donas son doblemente causantes de cáncer. Primero porque son elaboradas con flúor, azúcar refinada y aceite hidrogenado, después son FRITAS a altas temperaturas. Las donas son el primer "alimento" de todos los que puedas comer, que elevarán altamente tu riesgo de generar cáncer.
4. Papas fritas
Así como las donas, las papas fritas son elaboradas con aceites hidrogenados y cocinadas después a altas temperaturas. También contienen acryl amidas, que se generan durante el proceso de cocción a altas temperaturas. Deberían llamarse papas cáncer en lugar de papas fritas.
5. Colaciones y galletas
Todas estas son usualmente elaboradas con fluor y azúcar. Hasta las que en sus etiquetas son orgullosamente presentadas como libres de grasas transgénicas, generalmente lo contienen solo que en cantidades menores.


HÁBITOS QUE DAÑAN EL CEREBRO (matan neuronas)

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